Protective effects of topical antimicrobials against neonatal tetanus

Protective effects of topical antimicrobials against neonatal tetanus.

BACKGROUND Case-control studies previously conducted in Pakistan suggested that topical antimicrobials might provide protection against neonatal tetanus (NNT) when applied to the umbilical cord wound during the first several days of life. The present case-control study, the largest such study yet reported, was undertaken in Punjab Province, Pakistan and afforded further opportunities to evaluat...

Neonatal tetanus despite protective serum antitoxin concentration.

Using the ELISA technique to estimate serum antibodies against tetanus toxin, seven neonates with clinical tetanus were found to have antibody levels 4-13 times higher than the presumed minimum protective level of 0.01 IU/ml. All but one of their mothers had been vaccinated with tetanus toxoid in pregnancy. In two other neonates, whose mothers had received multiple booster doses of toxoid durin...

Topical Antimicrobials in Wounds

Wounds are a major cause of morbidity especially diabetic foot wounds. Topical antimicrobials are frequently used in day to day practice mainly in management of wounds by various healthcare professionals ranging from general practitioner to specialist surgeons. However lot of controversies exists regarding the usage of antimicrobials. This article provides an insight on the usage of various com...

Tetanus toxoid coverage as an indicator of serological protection against neonatal tetanus.

OBJECTIVE A Multiple-Indicator Cluster Survey (MICS) was conducted at mid-decade in more than 60 developing countries to measure progress towards the year 2000 World Summit for Children goals. These goals included the protection of at least 90% of children against neonatal tetanus through the immunization of their mothers, as measured by tetanus toxoid (TT) coverage. In the Central African Repu...

Eliminating Neonatal Tetanus